Estimating equations like the MDRD equation play an important role in CKD diagnosis and treatment. “The CKD-EPI equation has lower bias, especially at higher estimated GFR,” Dr. Levey explained.

Compared with the MDRD Study equation, the CKD-EPI equation reclassified 24.4% of general-population participants, 15.4% of high-risk patients, and 6.6% of CKD patients to a higher eGFR category ...

When eGFR was calculated using creatinine and cystatin C and without adjusting for race, adults with eGFR less than 60 mL/min/1.73 m2 had greater risk for dementia, but not for stroke, than those ...

Key takeaways: C-statistics were .750 during 2 years in a 4-variable model and .756 in an 8-year model. The risk equation outperformed the eGFR-based strategy across various net benefit thresholds.