and E-cadherin germline mutations in cases of familial diffuse gastric cancer argue strongly in favor of a real tumor suppressor role for E-cadherin, in addition to its role as an invasion suppressor.

E-cadherin is a transmembrane glycoprotein involved in epithelial cell adhesion. In cancer, downregulation of this protein enhances tumor cell dissociation, thereby increasing the risk of ...

There is a trial of strength at the cellular level. Cells are in constant competition with each other and so eliminate ...

Northwestern Medicine investigators have uncovered new insights into how intercellular "glue" functions to enable ...

“We are excited to share groundbreaking data on SOT109, an innovative ADC designed to treat colorectal cancer and other GI ... incorporating the SYNtecan E™ proprietary linker-payload system ...