One distinct feature of transcription factors is that they have DNA-binding domains that give them the ability to bind to specific sequences of DNA called enhancer or promoter sequences.

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event ...

By elucidating the role of the HNH nuclease domain and revealing the structural changes that occur upon DNA binding, this work not only deepens the understanding of CRISPR-Cas5-HNH but also paves ...

A typical TF has multiple functional domains, not only for recognizing and binding to the appropriate DNA strand, but also for interactions with other TFs, with proteins called coactivators ...

INOVIO (NASDAQ: INO), a biotechnology company focused on developing and commercializing DNA medicines to help treat and protect people from HPV-related diseases, cancer, and infectious diseases, today ...

Researchers have identified an ancient RNA-guided system that can target DNA, potentially expanding the genome-editing toolbox.

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...