Adenylyl cyclase creates multiple cyclic AMP molecules, which fan out and activate protein kinases (PKA, in this example). Protein kinases can enter the nucleus and affect transcription.
Conversely, treatment with GLP-1 led to increased levels of PDX-1 and several factors involved in glucose ... the cyclic AMP and phosphatidylinositol-3-kinase signal transduction pathways, but ...
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