Translocations generate novel chromosomes, but are often linked to disorders like infertility and cancer. How do these new chromosomes generate problems, and how are they detected? Translocations ...

A century after Down syndrome was first described, scientists discovered that the root cause of this disorder ... to a second chromosome, usually chromosome 14 or 15. When the translocation ...

The United Nations notes that each year, approximately 3,000 to 5,000 children are born with this chromosome disorder ... genetic variation is known as translocation Down syndrome.

Inherited retinal degeneration (IRD) encompasses various disorders characterized by progressive loss of retinal photoreceptor cells, ultimately leading to vision loss and blindness.

Genetic Abnormalities in B- and T-Cell Lymphoproliferative Disorders (LPDs ... BCL6, or CCND1 translocations. Burkitt lymphoma is driven by MYC rearrangements, confirmed via FISH.

Down syndrome stands as the most prevalent genetic disorder since the Centres for ... body cells contain an extra chromosome, while in translocation Down syndrome, chromosome 21 combines with ...

Scott W. Stuart, MD, MS; Casey H. King, BA; G. Shashidar Pai, MD Such observations emphasize the importance of clarifying the origin of a genetic variation by studying the parents for comparison.