Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can ...

Scientists at St. Jude Children’s Research Hospital used a series of cryo-EM structures to visualize dynamics pivotal to ...

Therefore, chromatin is further coiled into an even ... Part of the problem lies in the fact that electron microscopy is perhaps the best way to visualize packaging, but individual nucleosomes ...

April 3, 2025) Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this ...

During interphase, individual chromosomes are not visible, and the chromatin appears diffuse ... developed for visualizing spindles using electron microscopes (Mitchison & Salmon, 2001).

Therefore, understanding the chromatin structure-based mechanisms that regulate the use of the genetic information is crucial for designing new therapeutic strategies. Based on advanced cryo-electron ...

Cryo-Electron Microscopy Innovation Laboratory (CEMIL ... at MSK and support efforts to define the epigenetic mechanisms that alter the state of chromatin and regulate transcription in normal and ...

PALM has been applied to investigate the nanoscale organization of chromatin in the nucleus ... The integration of PALM with other imaging modalities, such as electron microscopy and Raman ...