Scientists have solved a decade-long question about the mechanism that preserves the centromere, the hub that ensures DNA ...

Without centromeres, cells cannot divide properly and the overall process of mitosis fails. Why are these small chromosomal regions so essential to such a major cellular process? With a few ...

Michael Lampson, PhD is a cell biologist at the University of Pennsylvania. His research group focuses on cell division, centromere function in the germline, and the cell biology of meiotic drive.

“They are fast evolving, and no one really knows why,” Dalal said. The team have yet to decipher which of these centromere characteristics predispose cells to faulty chromosome splitting during cell ...

During anaphase, the sister chromatids are separated simultaneously at their centromeres. The separated chromosomes are then pulled by the spindle to opposite poles of the cell. Anaphase ensures ...

Centromeres are chromosomal domains that link pairs of sister chromatids together during cell division. When cells divide, centromeres are pulled to opposite ends of the cell. Once divided, ...

A genomic study of human and selected nonhuman primate centromeres has revealed their unimaginable diversity and speed of ...

The stages outlined in the following example show a cell with a diploid chromosome ... attached to each other by their central region: the centromere. As long as they remain attached to each ...

Large-scale structural features of chromosomes including the arrangement of important chromosomal sites (origins, termini and centromeres) and overall chromosome compactness change dramatically and ...