At any one time, a cell is receiving and responding to numerous signals, and multiple signal transduction pathways are operating in its cytoplasm. Many points of intersection exist among these ...

Stark, Cleveland Clinic Foundation Research Institute; and Zhong Zhong, Columbia University College of Physicians and Surgeons These papers are two among a host of highly cited reports on the subject ...

These most often wind up controlling an event in the cell nucleus. The checks and balances of these signal transduction pathways can be thought of as overlapping networks of interacting molecules ...

Members of the program engage in research aimed at obtaining a mechanistic understanding of signal transduction and cellular regulation, which includes cellular signaling pathways and downstream ...

The regulation of gene expression and signal transduction pathways play a fundamental role in cellular survival and adaptability across all living organisms, from single-celled bacteria to complex ...

While much is known about pluripotency—the ability to differentiate into any other cell type in the body and to divide indefinitely—in terms of transcriptional and epigenetic regulation, as well as ...

The main goal of our laboratory is the identification and characterization of signal transduction pathways that cause ... Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis ...