Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

We demonstrated that the RNA binding protein hnRNPM reprograms alternative splicing including CD44 and promotes a breast cancer metastatic phenotype. By competitive binding on cis-regulatory RNA ...

The presence of such sequences in the EST databases may be the result of genuine alternative splicing events or pre-mRNA contamination of preparations used to construct libraries. We therefore ...