Sclerosteosis is a rare genetic disorder that causes excessive bone growth, leading to life-altering complications, including hearing loss and facial paralysis.

The Wnt/β-catenin signaling pathway plays an important role in bone formation. Signaling is initiated by the binding of Wnt to a Frizzled receptor as well as a low-density lipoprotein receptor ...

Based on these findings, the team examined whether the Notch signaling pathway controls SSPC differentiation ... the team found upregulation of bone formation genes which might prime the SSPC for ...

signaling in the pathogenesis of OPLL, particularly the type I IFN pathway, which is known to play a role in innate immune responses and bone formation. A single-cell transcriptome profiling study ...

Sclerosteosis arises from mutations in the SOST gene, causing abnormally high bone mass and skeletal overgrowth, which can lead to severe health issues such as hearing loss and increased intracranial ...

A landmark review in Nature Reviews Genetics dissects the rare and common genetic variants that shape human height. The paper ...

In this long-term work, the researchers demonstrated that the NOTCH signaling pathway, conserved throughout the evolution of all multicellular organisms, plays an essential role in the ...

IFN-γ, however, is known to cause both bone resorption and bone formation, and studies that ... via an indirect pathway—IFN-γ stimulates antigen-dependent T-cell activation, which results ...

Neha Dole, an assistant  professor in the departments of Physiology and Cell Biology, Orthopaedic Surgery and Pediatrics at the University of Arkansas for Medical Sciences, will speak at 12:55 p.m.

Studies suggest that by acting as a decoy receptor for myostatin—a protein believed to inhibit muscular tissue development—ACE-031 may offer novel avenues for research into wasting disorders that ...

Estrogen functions through binding of two different estrogen receptors (ESRs), ESR1 and ESR2. Estrogen plays an important role in bone biology, best illustrated by three points of observations ...