January 4, 2012 (Toronto, ON) — Canadian researchers have discovered that the BRCA1 gene is an essential regulator of cardiac function, at least in mice, and may therefore represent a new ...

Novel role of BRCA1 in tumor suppression Mechanisms by which the gene prevents breast and ovarian cancers understood Date: October 25, 2024 Source: University of Texas Health Science Center at San ...

BRCA1 belongs to a family of tumor suppressor genes, which make proteins that mend damaged DNA. Generally, a single functioning copy of a gene is sufficient to ensure normal function even when the ...

BRCA1 belongs to a family of tumor suppressor genes, which make proteins that mend damaged DNA. Generally, a single functioning copy of a gene is sufficient to ensure normal function even when the ...

BRCA1 is believed to be one of these repair proteins. In cells that have lost BRCA1 function, there are increased rates of mutation in response to DNA damage, and therefore a greater ...

Background: BRCA1 plays an important role in regulation of DNA repair. Its loss-of-function mutations are the cause of hereditary breast cancer and are also frequently observed in basal-like breast ...

“If it were, cancer would have developed at the same time in both groups of mice.” The observation suggested that it was not just the spontaneous loss of BRCA1 function that accelerated cancer. The ...

Genes get passed down from parents, determining traits such as eye color and height as well as risk for certain diseases.

People inherit two copies of each gene — one from each parent — an evolutionary fail-safe to ensure survival even when one of them doesn’t function. For cancer-suppressor genes like BRCA1, researchers ...