This raises a question if dose reduction ... of either apixaban or rivaroxaban for extended management of blood clots, noting this was a "weak recommendation" with "very low certainty evidence." ...

Purpose The pharmacology, pharmacokinetics, efficacy, and safety of apixaban are reviewed ... the need for anticoagulation monitoring or dosage adjustment. Apixaban has multiple elimination ...

for stroke prevention in low-risk patients (CHA2DS2-VASc score of 0–1). Novel anticoagulants include dabigatran, rivaroxaban and apixaban. Based on the RE-LY study, a 150-mg dose of dabigatran ...