Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

Aldosterone antagonists (spironolactone, eplerenone) also known as “potassium sparing diuretics” block the action of aldosterone inhibiting the reuptake of sodium and water. Normally ...

Other recent outcome studies document that resistant hypertension is not rare. In the Controlled ONset Verapamil INvestigation of Cardiovascular End Points trial (CONVINCE), [2] more than 16,600 ...

That is the conclusion of the Advance-HTN study reported at the American College of Cardiology (ACC) meeting, which found ...

It’s classified as a potassium-sparing diuretic and an aldosterone antagonist. Spironolactone is approved by the Food and Drug Administration (FDA) to treat heart failure, particularly severe ...

Although the aldosterone antagonist is widely used by many dermatologists as a hormonal approach to acne -- backed by various studies supporting efficacy -- the application remains off label.

The RAAS can be blocked by angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers, and aldosterone antagonists, as described in Treatment below. Both A-type (ANP ...

BLA accepted for Priority Review Finerenone (Bayer) Nonsteroidal mineralocorticoid receptor antagonist Treatment ... Highly selective aldosterone synthase inhibitor that reduces aldosterone ...

The finding that angiotensin II and aldosterone are proinflammatory ... angiotensin-receptor blockers (ARBs), mineralocorticoid-receptor antagonists, and direct renin inhibitors, all of which ...