Aβ immunotherapy, Aβ-aggregation inhibitors, allosteric modulators of γ-secretase and Aβ-degrading proteases can all reduce oligomeric Aβ, consequent neuronal degeneration and behavioural ...

and treatment with a selective γ-secretase inhibitor abolished the effects of GPR3 on Aβ secretion. The authors also showed that GPR3 expression in mouse hippocampus increased Aβ production ...

These Aβ-fragments accumulate in neurons early ... "The failure of clinical trials using gamma-secretase inhibitors may be explained by the fact that we were focusing on only one culprit and ...

Lilly's gamma secretase inhibitors semagacestat was a high profile ... and is called N3p-G-Aβ, another monoclonal antibody targeting beta amyloid. Alzheimer's disease is characterised by the ...

A Nigerian researcher, Isreal Onifade, has identified plant compounds that could help in the treatment of Alzheimer’s disease.Onifade’s study found that certain plant alkaloids can block β-secretase, ...

βCTF is a substrate for γ-secretase, and is cleaved in its transmembrane domain to form AICD and the potentially toxic Aβ. Mutations in presenilin ... This approach has been used to characterize ...